What is the purpose of using the drug "Gemaza" inophthalmology? Instructions for use and the purpose of this medication will be listed below. Also you will learn about the form of release of the said remedy, contraindications to its use and side effects.
The drug "Hemaz" (instructions for the use of this drug is mandatory for study) contains recombinant prourokinase, as well as additional substances such as dextran 40 and sodium chloride.
The medicine in question isform of lyophilizate, which is a white amorphous or porous mass, which has no odor and is intended for preparation of an intravenous solution.
The drug "Hemaz" in ampoules of glass is placed in contour cells or plastic pallets, which are sealed in packs of cardboard.
Also it should be said that this medication presupposes the presence of a special substance - a liquid that is diffused in vials.
How does the "Hemaz" medication work? The instruction for use states that the action of this enzyme agent is due to its active component - prourokinase. It is an enzyme - a serine protease. According to the chemical structure, this substance is a single-molecule molecule (with a molecular weight of 54 thousand Daltons), which includes two polypeptide chains that are connected by a disulfide bridge with molecular masses of 20 and 34 thousand Daltons.
The principle of operation of this tool is based onspecific stimulation of the conversion of profibrinolysin into the fibrinolytic component of plasma - fibrinolysin, as well as in the ability to destroy fibrin clots.
How is local absorption of the drug taken?"Hemaz"? Instructions for use asserts that the peak concentration of this drug in the tissues of the optic organs is achieved after two hours, and half a day later its traces can be found in the patient's blood.
The half-life of recombinant prourokinase is about 6 hours. It should be noted that due to the use of small dosages of the drug, it is impossible to achieve its systemic influence.
The use of this drug in ophthalmic practice is due to its high effectiveness in the following cases:
In what cases should you not prescribe a "Hemaz" medication? Instructions for use (injections should only be carried out by an experienced specialist) indicates the following prohibitions:
How should we use thismedicine? To do this, the contents of 1 ampoule must be diluted in 0.5 ml of 0.9% sodium chloride solution. The resulting solution will be equal to a dose of 5 thousand ME.
The introduction of such a drug should be subconjunctival (that is, under the conjunctiva) or parabulbar (that is, in the region of the lower eyelid).
The duration of therapy with this drug is 10 injections per course (not more).
How to apply "Hemazu" for the purpose of washingwith hyphema or massive sweat of fibrin in the front of the visual organ? To do this, take 0.2 ml of the drug with diluted lyophilizate and bring it to 0.5 ml with 0.9% sodium chloride solution.
For intravitreal administration of this medicationuse 0.1 ml of the solution and dilute it with 0.1-0.2 ml with 0.9% sodium chloride solution. Such a drug can be used once in hemophthalms of different genesis and fibrinoid syndrome.
It is impossible not to say that the drug"Gamaz" (the description of the drug was presented above) is often used as a prophylactic agent in the adhesion process after antiglaucomatous interventions. To do this, it is bred in the same ratio as for subconjunctival administration. After that, the medication is injected into the filtration pad at the very beginning of the postoperative period.
In the process of treatment with the drug "Hemaz" the patient can develop allergic reactions in the form of:
With a single administration of the drug in question at a dosage of more than 5,000 IU, the risk of developing allergic reactions that have been described in adverse events is significantly increased.
In case of surgical interventions and in the case ofoverdose on the background of treatment with this drug in order to reduce the risk of hemorrhage, it is recommended to additionally apply the medication "Etamsilat" in the form of intramuscular injections (in a dosage of 250-500 mg).
It is strictly forbidden to use "Gemazu" with injections of "Collalysin". With other thrombolytics, use this medication with extreme caution.
In one syringe, you can not mix two drugs at once (except for "Dexamethasone").
With the development of bradycardia or arterial hypotension, it is necessary to suspend the introduction of the medication before the normalization of heart rate and blood pressure.
How can I replace the medication in question? Its analogues are such drugs as "Aktilis", "Fibrinolizin", "Metalez" and "Trombovazim".
What people say about this tool are people whosuffer from problems with the visual organs? Most often reviews about this drug are left by those who use it for hemorrhages in ophthalmic practice. In this case, patients claim that such injections are very effective and effective. They are good at helping and completely coping with the task.
Despite all the unpleasantness of the treatment procedure (such injections are quite painful), patients are advised to suffer a little, and not to bring their condition to the removal of the vitreous.
As for negative reviews about thisthen most often they are associated with the development of side effects, as well as the presence of a huge number of contraindications. In addition, many patients believe that the cost of the drug "Gemaza" is too high (it costs about 750-850 rubles).</ p>>